Endocrine-disrupting chemicals (EDCs) have emerged as a major area of research in toxicology and environmental health because they can interfere with hormonal signaling and biological processes essential for health throughout the lifespan. Endocrine Disruption by Chemical Exposure presents a multidisciplinary examination of the biological consequences of EDC exposure, extending beyond classical endocrine and reproductive effects to encompass reproductive health, epigenetic regulation, metabolic disease, and cardiovascular pathology. The book explores the effects of chemical exposure on male and female reproduction, addressing the potential disruption of reproductive development, hormonal regulation, reproductive function, and fertility. It further examines epigenetic mechanisms associated with EDC exposure, providing insight into how environmental chemicals may influence gene regulation and potentially persistent biological responses. The book explores the relationship between endocrine disruption and metabolic diseases through interconnected pathways governing energy homeostasis, metabolism, and endocrine signaling. A dedicated focus on atherosclerosis examines potential links between exposure to endocrine-active chemicals and cardiovascular processes. Bringing together perspectives from toxicology, molecular biology, reproductive science, metabolism, and cardiovascular research, this volume provides a comprehensive framework for understanding the complexity of endocrine disruption. The book will be valuable to toxicologists, pharmacologists, biomedical and environmental researchers, clinicians, public health professionals, regulatory scientists, and graduate students seeking an up-to-date multidisciplinary perspective on the mechanisms and health implications of chemical-induced endocrine disruption.