The Genome Revolution was a major historical event that improved people's lives, from healthcare to industrial and food production. Recent advances in gene editing technologies have contributed to this process by allowing the modification of specific genes and genomes, improving the characteristics of organisms. These include treating genetic diseases, developing stress-resistant plants, and producing heat-resistant bacterial enzymes, among others. This book aims to compile the history of genome editing technologies and current gene editing approaches. Current and future ethical concerns are also addressed. The book provides up-to-date information on gene editing technologies and their applications, serving as a platform for the scientific community interested in genome studies. With this book, we aim to bring together up-to-date information on genome editing for researchers working in genomics, molecular biology, medicine, biotechnology, pharmacology, and related fields.