With the increase in the incidence of chronic diseases like cardiovascular disorders, neurodegenerative conditions, and cancers as one lives longer, healthy ageing has become a concern. Curcumin, derived from the rhizome of the Curcuma longa plant, can combat oxidative stress, inflammation, and immune dysregulation, and help control age-related pathologies. The book Health Benefits of Curcumin describes the unique structural features of curcumin, which make it a promising antiviral agent for combating the COVID-19 pandemic, treating Parkinson’s disease (PD) and Alzheimer’s disease (AD), and potentially treating cancer patients using novel nano-curcumin delivery systems with multi-targeting capabilities. Finally, the book discusses how to break the immunosuppressive environment of the tumour microbiome, which the tumour uses to survive, by using curcumin-induced gut microbiota metabolites.