As countries around the world find themselves grappling with sociotechnological shifts—the Fourth Industrial Revolution—science, technology, and innovation policy (STI) is at the intersection of local and global challenges. The authors of Innovation Policy at the Intersection call for a comprehensive rethinking of STI policy in order to meet those challenges. Highlighting the experiences of a broad spectrum of countries around the world, they identify the need for a coherent, systemic approach that brings together the global and the local, the theoretical and the practical.