Bone tumor approaches are rapidly evolving, driven by better imaging (PET/MRI, AI), molecular genetics for targeted therapy, and refined multidisciplinary care. However, surgery, chemotherapy, and radiation remain standard, with new research focusing on local delivery systems (such as gallium-infused glass) and on understanding specific tumor genetics to improve outcomes, emphasizing early, expert center management. This book is unique in its summary and update of a modern approach to bone tumors and their therapeutic strategies.