This book offers a comprehensive and up-to-date analysis of the HIV/AIDS epidemic, covering everything from epidemiology and prevention to the clinical and psychosocial aspects of disease management. With a global focus, it brings together research and experiences from different regions, highlighting the particularities and challenges faced in various contexts. It is organized into three sections. The first section is dedicated to understanding the epidemiological patterns and trends of the infection, providing detailed analyses on the dynamics of transmission, risks, and perceptions of care, with field studies conducted in Nigeria and China. In the second section, the focus is on practical strategies for prevention and treatment, including innovations in pre-hospital testing, the role of clinical pharmacy, and efforts to eliminate vertical transmission by 2030. Finally, the third section addresses specialized clinical management, highlighting associated neurological conditions, management of drug interactions, and mental health needs in the most vulnerable populations, especially in low- and middle-income countries. Integrating epidemiological, clinical, and psychosocial knowledge, the book is an essential resource for professionals, researchers, and policymakers seeking effective and humanized solutions to address HIV/AIDS. The book contributes to the advancement of practices that improve the quality of life for people living with HIV worldwide.