This book provides a comprehensive overview of hepatitis C infection. It includes two sections. The first section includes four chapters that discuss the structure, diagnostic methods, phylogenetic classification, and multiscale viral dynamics modeling of the hepatitis C virus and its interaction with host genetics. The second section includes four chapters that summarize the existing strategy of hepatitis C virus elimination, management of hepatitis C virus in patients with chronic kidney disease, and association of hepatitis C virus with hepatic and extrahepatic malignancy. This book is a useful resource for investigators studying hepatitis C infection and physicians treating the disease.