Healthcare has existed throughout human history and has evolved into a complex system that requires collaboration among multidisciplinary healthcare professionals. The principle of "first-do-no-harm" (Primum non nocere) remains fundamental. Providing quality and safe services and ensuring patient safety are vital. Patient safety is possible through a strong safety culture and continuous improvement. Rapidly developing technology and digital transformation have propelled hospital management towards visionary leadership. Managers must adapt to innovations while using resources efficiently. This book offers a general framework, grounded in an interdisciplinary approach, that combines theoretical foundations and practical applications in hospital management and patient safety.