This professional technical book compiles a set of technical chapters that capture and provide an overview of the current Decision Support Systems (DSS) and the recent developments of DSS tools to aid complex decision-making processes across various domains, including airport performance analysis, decision analysis under uncertainty, agricultural planning, modeling human and social decisions, clinical diagnostics, corporate power dynamics, AI on the edge, and manufacturing scheduling. The book is intended to serve as a reference for educators, engineers, scientists, and researchers in STEM fields, particularly in DSS, algorithms, and tools, who would benefit from its rich technical content and open problems. It offers insights into new methodologies essential for navigating the complexities of today's DSS landscape.