This book presents the new advances and new perspectives of personalized medicine, emphasizing personalized, predictive medicine, personalized preventive medicine, personalized therapy, and personalized diagnosis/prognostic assessment. The research and practice of multiomics-based pattern biomarkers will significantly contribute to personalized medicine, including deeply addressing the accurate molecular mechanism, stratifying the patients, discovering effective biomarkers, and determining the effective therapeutic targets/drugs for patients to significantly benefit the patients and their families to reduce the medical cost and improve the life quality of patients.