This book, Drug Metabolism and Pharmacokinetics, delivers the latest information on biotransformation and other pharmacokinetic parameters required to assess drug safety in drug discovery and development. Drug metabolism and pharmacokinetics (DMPK) is considered a rational strategy for the design, optimization, and selection of successful drug candidates in the pre-clinical stages of drug discovery. The evaluation of various pharmacokinetic parameters such as aqueous solubility, lipophilicity, cell permeability, bioavailability, protein binding, and

metabolism and elimination half-life, drug–drug interactions (DDIs), and toxicokinetics is essential for a candidate drug to become a successful therapeutic agent. This book discusses recent advances in in-silico tools and in vitro/in vivo experimental techniques applied in

pharmacokinetic, metabolomic, and bioanalytical studies.

Key Features:

• Presents pharmacokinetic and biotransformation parameters used for pre-clinical safety

evaluations

• Depicts experimental and biophysical techniques used in bioanalytical and metabolomic

studies

• Summarizes in silico, in vitro, and in vivo methods used in drug–enzyme interactions, drug–

drug interactions, and toxicokinetics

Written by a global team of experts, this book is a valuable resource for drug discovery scientists,

drug developers, medicinal chemists, pharmacologists, biochemists, clinicians, biomedical

scientists, healthcare professionals, researchers, teaching faculty, and students.