The book introduces and discusses new drugs for radical cure of HIV/AIDS. It also discusses the problems and challenges of these treatments. Chapters address problems related to the use of antiplatelet therapy in HIV treatment, gene-based therapies as the most promising candidates for the ultimate cure of infection, obesity as an emerging public health problem among people living with HIV/AIDS, and the pathogenesis of immune reconstitution inflammatory syndrome (IRIS) with special reference to Hodgkin’s lymphoma (HL), which frequently occurs following successful treatment of HIV with highly active antiretroviral therapy (HAART).