The prayer of the heart is an early Christian contemplative tradition of striking profundity and beauty. Christian authors of the Greek- as well as the Syriac-speaking world placed the heart at the center of a mystical theology that viewed the body as a God-given instrument of divine ascent and the relational setting of Christian existence as an important means of experiencing God’s abiding inner presence. This work sheds light on the Syrian church’s approach to the mystery of the divine encounter.